Adjunctive Therapy- Melatonin, Clemastine and other good stuff

Melatonin


Please see the article below for detailed information on how Melatonin is neuro-protective in not just MS, but many neurological diseases with inflammatory components including dementia, Alzheimer Disease (AD), Parkinson's disease, MS, stroke, TBI (Traumatic Brain Injury) and SPI (spinal cord injury).

http://www.docstoc.com/docs/document-preview.aspx?doc_id=168700246

Melatotonin is a naturally occurring hormone produced by the pineal gland in the brain. Many MS patients have been found to be deficient in Melatonin. Even if you are not found to be deficient Melatonin has been proven to be a strong anti-oxidant and immune modulator.

Dosages would start at 3-10mg per day at bedtime. Melatonin has been used in much higher doses for ALS (300mg/dy) and also in conjunction with IV steroids, to lower the amount of steroids needed- see page 233 right column, near the bottom for this dosage.

Melatonin has been under study for many years. Please consult your GP or neurologist concerning dosage and suitability in your unique case.

Tavist (Clemastine) 4mg twice daily

This is an antihistamine that has fallen out of use. It is believed to promote oligodendrocytes into producing more myelin. There is a study currently enrolling at UCSF. See here for more details. 

Side effects include: fatigue, tremor, hypotension, headache, blurred vision, nausea, bowel changes (diarrhea or constipation), difficult urination, wheezing, dryness of mouth, nose & throat. 

SSRIs (selective serotonin reuptake inhibitors- ie Prozac, Lexapro) 

Article on Prozac:

http://www.docstoc.com/docs/170341482/Effects-of-fluoxetine-on-disease-activity-in-Relapsing-MSpdf

Depression is an inflammatory process:
 http://www.docstoc.com/docs/170341656/Inflammation-and-its-Discontents-The-Role-of-Cytokines-in-the-pathophysiology-of-major-depressionpdf

Anti-inflammatory/anti-oxidative stress vitamins. 

I tried to find one article that would give both vitamins and dosages for many 'anti-oxidant' active vitamins but was unable to find such an article with things so easily defined. I will pull together the vitamins I take following years of personal research and neurologists recommendations.